AGING and INCREASING population ... the global balance of science. Established ... •Broad Institute, Evotec, Targenomix...

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Collaborative [email protected] On the benefits of ambition and the power of the difference Monika Lessl, Bayer AG, Head Corporate Innovation and R&D – Innovation partnerships between Science and Industry- looking jointly into the crystal ball - Leverkusen, Nov 7, 2016

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Collaborative [email protected] • October 2016

Longterm success is driven by both - Stability and Agility

to run the daily business and maximize value

to adapt to a changing environment and develop new business options

„Science For a Better Life“ Page 3

Collaborative [email protected] • October 2016

Bayer has a strong commitment to R&D Animal Health ~€0.13bn

27%

Crop Science ~€1.1bn

Pharmaceuticals ~€2.45bn

6% 61%

Consumer Health ~€0.25bn

Almost 14.000 people working in R&D Page 4

Collaborative [email protected] • October 2016

Innovation has been and will be a key driver for our success

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Collaborative [email protected] • October 2016

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Collaborative [email protected] • October 2016

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Collaborative [email protected] • October 2016

The environment is changing at a rapid pace AGING and INCREASING population

DIGITALIZATION drives business Innovation

SOCIETAL CHANGES Increasing influence of NGOs

Self determination of consumers

“CONSUMERISM” Page 8

Collaborative [email protected] • October 2016

VALUE REQUIREMENTS lead to new business models (pay for performance)

DISRUPTIVE TECHNOLOGIES and BIG DATA transform R&D

NEW ENTRANTS in established markets

We innovate in everything we do BUSINESS MODEL INNOVATION

PROCESS INNOVATION Driving innovation in how we operate

Product Innovation driven by strong R&D

SERVICE INNOVATION Providing innovative services to our customers Page 9

Collaborative [email protected] • October 2016

Evaluating new business models

We promote Innovation along the value chain: [email protected] is driven by 4 key success factors

Research

Development

Strong R&D capabilities

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Collaborative [email protected] • October 2016

Product Supply

Marketing

Sales

Collaborative Ecosystem

The collaborative ecosystem has just started

New collaboration patterns are changing the global balance of science. Established superpowers need to keep up or be left behind, says Jonathan Adams. Nature Vol 490, 2012

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Collaborative [email protected] • October 2016

Requirements of a Collaborative ECOSYSTEM

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Collaborative [email protected] • October 2016

Bayer HealthCare’s approach of flexible partnering models to meet the individual needs of the partners

• Joint labs

CLOSE INTERACTION, SHARED LABS

• DKFZ

• Strategic innovation partnership • Consortia

MULTIPLE PROJECTS, CLOSE INTERACTION

• Broad Institute, Evotec, Targenomix • Innovative Medicine Initiative

• Joint research • Crowdsourcing

INDIVIDUAL PROJECT

• Singapore Network • Grants4platform

• Licensing

• • • •

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TRANSITION OF ASSETS

Build to Buy model Incubator Venture Investments Joint Ventures

Collaborative [email protected] • October 2016

ARM‘S LENGTH

• LDC Dortmund

• • • •

Inception4 Ophthalmology CoLaborator SF/Berlin Versant Ventures, HTGF, Finistere Bayer Life Science Center

Strategic partnerships with worldwide leading institutes: DKFZ -German Cancer Research Center - Bayer

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Collaborative [email protected] • October 2016

BHC – DKFZ: High strategic fit due to complementary expertise

• Drug discovery & development • Target validation strategies • Established technology platforms for target validation

• Assay development for HTS • Compound library and expertise in medicinal Chemistry

• Preclinical drug development and approval process; marketing and sales

Source: Wellenreuther, Keppler, Mumberg, Ziegelbauer & Lessl, Drug Discovery Today 2012, Vol 17, 1242-1248 Page 16

Collaborative [email protected] • October 2016

• Deep Knowledge on molecular mechanismus of cancer

• Innovative target ideas • Expertise in novel, emerging research areas (e.g. oncogenomics, cancer stem cells)

• Novel mechanistic assays • Clinical expertise (NCT) and capability to perform clinical studies

Strategic partnerships with worldwide leading institutes: Targenomix - Bayer

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Collaborative [email protected] • October 2016

We want to leverage emerging technology platforms to address 10 breakthrough ideas

1

Cure rare blood disorders

6

Retina regeneration

2

Cure monogenic blindness

7

Soil and root health

10 6 5

3

Cure congenital heart disease

8

Non-toxic insecticides

4

High speed crop breeding

9

Fast animal Vaccines

5

Scar-less cardiac healing

10

Plaque-eating macrophages

3 2

7

4

1

via the new Bayer Life Science Center Page 18

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8

9

December 21.2015 By John Carroll Page 19

Collaborative [email protected] • October 2016

Bayer Open Innovation Family Grants4Targets™

grants4targets.com

Grants for targets and biomarkers.

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Grants4Traits

Grants4Tech™

grants4traits.bayer.com

grants4tech.bayer.com

Grants for novel solutions to increase crop productivity.

Collaborative [email protected] • October 2016

Innovative technologies to support production in the life-science industry via e.g. robotic solutions.

Grants4indications

www.grants4indications.bayer.com

Grants to explore novel indications for Bayer compounds.

Grants4Apps®

grants4apps.com

Grants for innovative IT projects which may lead to new business models.

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Collaborative [email protected] • October 2016

Causes of alliances failures Poor legal, financial terms and conditions

11% Poor relationships • Low trust • Poor communication

52% 37%

Poor Stretagy, Business Planning

• Poor conflict resolution • Culutral differences

J. Weiss & L.J. Visioni, Vantage Partners

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Collaborative [email protected] • October 2016

We apply the RESOLVE¹ model for professional management of partnerships Value of Relationship and Culture

Enthusiasm/Commitment

MUTUAL BENEFIT Value Communication

AND

Strategic Fit

ADDED VALUE

Learning Capabilities

¹ Lessl & Douglas: Wissenschaftsmanagement. (2) 2010, p 34-41

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Professional Operational Management

It‘s all about people Let‘s join forces to make the world a better place

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Collaborative [email protected] • October 2016